Abcam, ab249754, Anti-CACNA2D2 antibody [EPR12343] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CACNA2D2 antibody. Carrier free. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12343,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249754 is the carrier-free version of
ab173293
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CACNA2D2 also known as calcium channel voltage-dependent alpha 2/delta subunit 2 is a protein involved in the function of voltage-gated calcium channels. This protein acts as an auxiliary subunit and plays a role in the regulation of the channel's currents. CACNA2D2 has a mass of approximately 129 kDa and is typically expressed in various tissues including the brain and heart. It shows significant involvement in neurons playing a role in neurotransmitter release due to its modulation of calcium entry into cells.
Biological function summary
CASNA2D2 is important for the function of nervous and cardiac systems. It forms part of a larger protein complex that includes alpha-1 beta and gamma subunits which all work together to influence calcium influx in response to membrane depolarization. This calcium entry is important for processes such as synaptic transmission and muscle contraction. CACNA2D2's modulation of calcium channels hence affects the excitability of neurons and the contractility of cardiac muscle cells impacting both neuronal signaling and heart function.
Pathways
The presence of CACNA2D2 influences the calcium signaling pathway and the cardiac conduction pathway. This protein modifies cellular processes by regulating the calcium ion concentration inside cells which can trigger various signaling cascades. It interacts closely with other proteins in these pathways like the L-type calcium channels which mediate significant increases in intracellular calcium levels. Such interactions further highlight its role in normal physiological responses to electrical stimuli in cells.
Alterations in CACNA2D2 expression or function can lead to epilepsy and cardiac arrhythmias. Changes in this protein's behavior can disrupt normal calcium homeostasis leading to altered neuronal firing patterns and impaired cardiac rhythm. Its relationship with epilepsy highlights its role as a potential target for anticonvulsant drugs aiming to stabilize neuronal firing. Similarly it connects with other proteins like CACNA1C in the context of cardiac diseases linking these proteins in the pathological manifestation of arrhythmias.