Abcam, ab249797, Anti-TAPP-1 antibody [EPR12061] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TAPP-1 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12061,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249797 is the carrier-free version of
ab174292
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAPP-1 also known as tandem PH domain-containing protein 1 is a signaling protein with a molecular weight of approximately 50 kDa. It features tandem PH domains that bind to phosphoinositides specifically PI(34)P2 which is a phospholipid signaling molecule. TAPP-1 is expressed in various tissues including the immune system cells such as lymphocytes and other hematopoietic cells. It plays an important role in the context of phosphatidylinositol signaling pathways.
Biological function summary
This protein is important for immune system functions and is involved in cellular signaling processes that govern cell survival proliferation and migration. TAPP-1 can exist as part of larger signaling complexes where it helps to scaffold proteins to phosphoinositide-rich membranes. This interaction directs the spatial and temporal assembly of signaling components critical for immune cell activation and response.
Pathways
TAPP-1 plays a role in PI3K (phosphoinositide 3-kinase) signaling an important pathway in the regulation of the immune response and cellular growth. Its activity impacts the AKT signaling pathway linking it to cell proliferation and survival functions. TAPP-1 works in concert with proteins like SHIP and BTK influencing their activity in the phosphoinositide signaling web that regulates immune cell behavior.
The regulation of TAPP-1 is significant in immune-related disorders and cancers as imbalances in PI3K signaling may lead to these conditions. Aberrant expression or mutation of TAPP-1 has been linked to leukemia where altered phosphoinositide signaling contributes to abnormal cell proliferation. Moreover it shows connection with SHIP through its involvement in immune dysfunctions pointing to a role in diseases like autoimmune disorders where immune signaling pathways are disrupted.