Abcam, ab249802, Anti-LIN7A antibody [EPR12609] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal LIN7A antibody. Carrier free. Suitable for IP, WB and reacts with Human, Rat, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12609,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249802 is the carrier-free version of
ab174297
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIN7A also known as Lin-7 homolog A or MALS-1 is a protein with a molecular weight of approximately 25 kDa. It plays a significant mechanical role in cell signaling and synaptic assembly. LIN7A primarily localizes at cell membranes with pronounced expression in the brain and heart where it participates in the development and maintenance of cellular polarity and tight junctions.
Biological function summary
LIN7A is involved in neuronal signaling and synaptic function. It forms part of the larger complex known as the membrane-associated guanylate kinase (MAGUK) protein family. In neurons LIN7A maintains receptor localization by interacting with synaptic proteins and is essential in stabilizing various complexes necessary for synaptic communication.
Pathways
LIN7A participates significantly in the MAPK and PI3K/Akt signaling pathways. These pathways are important in regulating cell growth and survival. LIN7A interacts with other proteins like DLG1 and CASK which are essential components in maintaining cellular signaling integrity within these pathways.
Disruptions in LIN7A expression or function have connections with neurological disorders such as schizophrenia and autism spectrum disorders. LIN7A’s interaction with other proteins such as DLG4 suggests its involvement in synaptic dysfunctions which are common characteristics in these conditions. Understanding LIN7A's roles in these disorders can potentially lead to targeted therapeutic approaches.