Abcam, ab249806, Anti-TRNP1 antibody [EPR11958] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TRNP1 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11958,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249806 is the carrier-free version of
ab174303
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRNP1 also known as Ternary Complex Factor Small Nuclear Ribonucleic Protein 1 is a protein involved in DNA-binding activities. It has a mass of approximately 25 kDa. TRNP1 is expressed in various tissues most predominantly in the brain and neural tissues. It acts as a transcription factor binding to specific DNA sequences and influences the expression of genes involved in brain development and neural cell proliferation.
Biological function summary
TRNP1 regulates the proliferation and differentiation of neural progenitor cells. This protein does not appear to form part of a larger protein complex but it directly affects cellular processes that shape the growth and arrangement of the cerebral cortex during embryonic development. Its expression levels can control the cellular architecture influencing neural tube closure and cortical folding.
Pathways
TRNP1 plays a role in neural development pathways and interacts significantly with the Wnt signaling pathway. It regulates genes that are important for maintaining the balance between neural progenitor cell proliferation and differentiation. In this pathway TRNP1 may have an interaction with proteins like Wnt and β-catenin that control cellular growth decisions affecting brain size and function eventually.
Alterations in TRNP1 levels or function relate to disorders such as microcephaly and possibly certain neurodevelopmental dysplasias. It has been suggested that imbalances in TRNP1 activity can disrupt cortical development leading to abnormal brain development. While comprehensive studies are ongoing TRNP1 potentially interacts with proteins associated with these disorders marking its importance in neural developmental research.