Abcam, ab249893, Anti-HID1/DMC1 antibody [EPR12901] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal HID1/DMC1 antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12901,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249893 is the carrier-free version of
ab175926
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HID1 also known as "hiding one" is a protein with a molecular mass of approximately 119 kDa. It plays an important role in intracellular trafficking and signaling. Researchers find HID1 expression mostly in neurons indicating a significant function in the central nervous system. Additionally HID1 is observed to localize within the Golgi apparatus suggesting its involvement in vesicular transport processes.
Biological function summary
HID1 regulates vesicle-mediated transport and neurotransmitter release. It is a part of a multi-protein complex involved in the cellular processes necessary for proper signal transmission between neurons. Within this context HID1 interacts with other endocytic proteins to ensure efficient synaptic vesicle recycling a process essential for maintaining synaptic function and plasticity.
Pathways
HID1's biological function integrates with the synaptic vesicle cycle and intracellular signaling pathways. Specifically it relates to the SNARE complex which is pivotal for vesicle docking and fusion events at synapses. HID1's association with the SNARE complex positions it as a significant factor in the regulation of neurosecretion and synaptic communication.
Research has linked HID1 to neurodegenerative diseases and potentially schizophrenia. Alterations in HID1 expression or function can impact neuronal communication and synaptic integrity contributing to these conditions. Moreover HID1 has shown a connection to the neurodegenerative disorder pathway alongside proteins like SNAP25 suggesting potential interaction or common involvement in disease mechanisms.