Abcam, ab249985, Anti-Kv1.1 potassium channel antibody [EPR12718] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Kv1.1 potassium channel antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12718,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249985 is the carrier-free version of
ab177481
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Kv1.1 potassium channel also known as Kv1 or Kv1s belongs to the voltage-gated potassium channel family. This channel with molecular mass of approximately 53 kDa plays an important role in the regulation of membrane potential and electrical excitability of neurons. Widely expressed in the central nervous system it is especially present in the nodes of Ranvier and axons of myelinated neurons contributing to the propagation of action potentials.
Biological function summary
The Kv1.1 channel is essential for controlling neuronal excitability and action potential repolarization. It functions by allowing potassium ions to flow out of the neuron which stabilizes the resting membrane potential. This channel often forms part of a heteromeric complex with other Kv subunits which fine-tune its biophysical properties. Such interactions enable it to modulate synaptic transmission and signal integration in neurons.
Pathways
Kv1.1 channels participate in the regulation of the action potential pathway and the synaptic transmission pathway. Through these pathways Kv1.1 interacts with protein partners such as the Kvβ subunits which can modulate the kinetics and voltage dependence of the channel. Its activity contributes significantly to the rapid repolarization of action potentials therefore maintaining the high-frequency firing ability of neurons.
Alterations in Kv1.1 channel function are linked to episodic ataxia type 1 and temporal lobe epilepsy. Mutations affecting the channel conductance or gating can lead to disrupted neuronal signaling. In these conditions Kv1.1 has been found to interact with related proteins like Kv1.2 and Kv1.4 which also play roles in neurological function. Understanding the Kv1.1 protein and its interactions is important for developing therapeutic strategies for these channelopathies.