Abcam, ab250132, Anti-FAM98B antibody [EPR12872] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal FAM98B antibody. Carrier free. Suitable for IHC-P, ICC/IF, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12872,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250132 is the carrier-free version of
ab179833
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAM98B also known as 'family with sequence similarity 98 member B' is a protein with an approximate mass of 55 kDa. It shows expression in several human tissues with notable levels in the brain liver and lungs. Mechanically FAM98B binds RNA and potentially acts as a scaffold for other protein interactions suggesting roles in RNA processing or regulation.
Biological function summary
FAM98B takes part in various cellular processes including the assembly of RNA-protein complexes. It associates with the CCR4-NOT complex a critical regulator of mRNA deadenylation and decay. Through these interactions FAM98B possibly influences mRNA stability and gene expression impacting cell growth and differentiation.
Pathways
Researchers have linked FAM98B to pathways like mRNA surveillance and cell cycle regulation. It interacts with proteins such as CNOT1 and other components of the CCR4-NOT complex. This association plays a role in monitoring mRNA integrity and the promotion of mRNA decay affecting cell proliferation and response to stress.
Alterations in FAM98B expression or function relate to cancer and neurodegenerative disease. In cancer abnormal levels of FAM98B might influence tumor growth by interacting with proteins like DDX20 affecting cell cycle regulation. In neurodegenerative disorders disruptions in pathways involving FAM98B could impact neuronal function possibly interacting with proteins within the CCR4-NOT complex to influence cognitive outcomes.