Abcam, ab250363, Anti-FUBP3 antibody [EPR13174-61] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal FUBP3 antibody. Carrier free. Suitable for IHC-P, ICC/IF, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13174-61,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250363 is the carrier-free version of
ab181122
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb
patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FUBP3 also known as Far Upstream Element Binding Protein 3 plays a mechanical role in cellular functions through binding to DNA and RNA. This protein belongs to the family of FUSE-binding proteins that regulate gene expression at the transcriptional and translational level. It has a molecular mass of about 65 kDa. FUBP3 is highly expressed in the nucleus of various cell types including neurons and immune cells reflecting its role in cellular processes.
Biological function summary
FUBP3 acts as a regulator of gene expression by interacting with RNA and influencing RNA stability and translation. It usually functions as part of a complex with other proteins modulating transcription factors that control cell growth and differentiation. Through these interactions FUBP3 can switch genes on and off significantly affecting cellular behavior and the cellular response to environmental changes.
Pathways
The function of FUBP3 contributes to the control of the cell cycle and apoptosis pathways. Within the cell cycle it acts alongside proteins like p53 to ensure cells progress correctly through various phase transitions. In the context of apoptosis FUBP3 interacts with Bcl-2 family proteins influencing cell survival and programmed cell death. These pathways show how FUBP3 coordinates with other proteins to maintain cellular equilibrium.
Deregulation of FUBP3 has connections to cancer and neurodegenerative diseases. Its abnormal expression can lead to tumor development by disrupting normal cell cycle and apoptotic control often involving interactions with the tumor suppressor protein p53. Furthermore alterations in FUBP3 function have links to neurodegenerative disorders potentially through interactions with tau proteins which are central to diseases like Alzheimer's disease.