Abcam, ab250454, Anti-TMEM256 antibody [EPR12842] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TMEM256 antibody. Carrier free. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12842,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IP, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250454 is the carrier-free version of
ab181239
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM256 also known as Transmembrane Protein 256 is an integral membrane protein with a mass of approximately 18 kDa. It localizes to the cell membrane where it spans the lipid bilayer with multiple transmembrane domains. Expression of TMEM256 is noted in several tissues with higher expression observed in the brain and testis. This suggests a role linked to specific tissue functions possibly related to signaling processes or transport mechanisms across the membrane.
Biological function summary
TMEM256 appears significant in modulating membrane potential and maintaining homeostasis. Though not part of a well-defined complex the protein's characteristics suggest involvement in maintaining cellular ion gradients. This may implicate TMEM256 in key cellular activities such as neuron signaling or other electrically excitable tissue functions. Its role suggests interactions with other membrane proteins which could further modulate its activity or be involved in cellular responses to the external environment.
Pathways
TMEM256 influences cellular signaling and membrane transport mechanisms. It is implicated in ion transport pathways and may interact with proteins like sodium-potassium pumps contributing to maintaining membrane potential. Additionally TMEM256 likely plays a role in neural communication pathways potentially interacting with proteins essential in synaptic function such as neurotransmitter receptors or ion channels suggesting coordination in neuron signaling and rapid response systems.
TMEM256 has links to neurological conditions and reproductive health issues. Aberrant expression or mutations in TMEM256 may connect to neurological disorders potentially through its role in modulating ion gradients and neuron excitability. Another aspect is the possible involvement in reproductive disorders due to its expression patterns in testis. The protein could interact with other disease-related proteins such as ion channels or transporters which are known to be associated with both neurological and reproductive health.