Abcam, ab250468, Anti-CRABP2 antibody [EPR14256(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CRABP2 antibody. Carrier free. Suitable for IHC-P, ICC/IF, WB, Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14256(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow Cyt (Intra), WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250468 is the carrier-free version of
ab181255
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cellular Retinoic Acid-Binding Protein 2 (CRABP2) mechanically facilitates cellular retinoic acid (RA) signaling by transporting RA to the nucleus. The protein is also known as CRABP II and is approximately 15 kDa in mass. You can find its expression in various tissues including skin adipose tissue and brain where it exhibits specific roles in RA signaling and cellular differentiation processes.
Biological function summary
CRABP2 participates in modulating the availability of RA which influences gene expression by binding to nuclear receptors. Although CRABP2 functions independently rather than as part of a larger protein complex it holds a significant role in gene transcription regulation. This active role in regulating RA levels impacts cellular differentiation and proliferation processes essential for tissue development and homeostasis.
Pathways
CRABP2 is an important participant in the retinoic acid signaling pathway. This pathway impacts important biological processes such as embryonic development and cell growth. CRABP2 closely interacts with the retinoic acid receptor (RAR) guiding RA to RARs and contributing to the regulation of gene expression. Moreover it is linked to the transforming growth factor-beta (TGF-beta) pathway playing a role in managing cellular apoptosis and differentiation.
Researchers associate CRABP2 with several cancers notably skin cancer due to its influence on cell proliferation. Altered expression or function of CRABP2 can also affect neurodegenerative diseases impacting pathways involving neuronal survival. CRABP2's interactions with proteins like RAR and in cancer contexts with overexpressed RA receptors highlight its relevance in modulating RA-dependent processes that can lead to pathological states.