Abcam, ab250547, Anti-CEECAM1 antibody [EPR13744] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CEECAM1 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13744,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250547 is the carrier-free version of
ab181979
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEECAM1 also known as Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 has a molecular mass of approximately 37-45 kDa. This glycoprotein belongs to the immunoglobulin superfamily and facilitates cell adhesion processes. CEECAM1 is mainly expressed in epithelial cells of several tissues including the gastrointestinal tract liver and lungs. It plays roles in cellular adhesion and signaling which are important for maintaining structural integrity and communication between cells.
Biological function summary
CEECAM1 participates in modulating immune responses and cellular proliferation. This protein interacts with other molecules at the cell surface to form complexes that influence cell signaling pathways. CEECAM1's involvement in processes such as cell adhesion and migration makes it significant in tissue architecture and homeostasis. Through these functions CEECAM1 has an influence on both normal physiological processes and pathological conditions.
Pathways
CEECAM1 is actively involved in the MAPK and PI3K/AKT signaling pathways. These pathways are critical for transmitting signals related to growth survival and differentiation of cells. In the MAPK pathway CEECAM1 interacts with proteins like ERK which regulates various cellular activities. Within the PI3K/AKT pathway CEECAM1 can influence activity impacting cell cycle progression and apoptosis. Its interactions within these pathways link CEECAM1 to a broader network of cellular functions.
CEECAM1 has associations with cancer progression and inflammatory diseases. In various cancers such as colorectal cancer CEECAM1 expression levels can change influencing tumor progression and metastasis. It often interacts with proteins like CEA (Carcinoembryonic Antigen) which is involved in tumorigenesis. In inflammatory diseases CEECAM1's role in modulating immune responses can alter inflammatory pathways affecting tissue damage and repair mechanisms. Understanding CEECAM1's role in these diseases continues to be an area of active research.