Abcam, ab250664, Anti-ARL2 antibody [EPR14436] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ARL2 antibody. Carrier free. Suitable for ICC/IF, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14436,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250664 is the carrier-free version of
ab183510
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
{ 'ARL2' } is a member of the ARF-like protein family and is also known as ADP-ribosylation factor-like protein 2. This small GTP-binding protein has a molecular mass of approximately 22 kDa. Researchers find it expressed in various human tissues including the kidney heart and brain. This wide expression suggests its relevance in multiple cellular functions. Through its involvement in microtubule dynamics ARL2 plays a role in cytoskeletal organization. Its presence in different cellular compartments is linked to diverse functions.
Biological function summary
{ 'ARL2' } is integral to intracellular transport and mitochondrial function. It forms a complex with other proteins such as cofactor D and ARL2BP to influence the stability and assembly of microtubules and assist in the correct folding of tubulin. ARL2 contributes to maintaining proper mitochondrial morphology and energy production. Additionally it participates in regulating apoptosis highlighting its versatility in cellular operations.
Pathways
{ 'ARL2' } functions within the MAPK/ERK signaling pathway which is vital for cell growth and differentiation. It also interacts with the mitochondrial import pathway cooperating with proteins like TOMM7 to regulate mitochondrial protein translocation. These interactions position ARL2 as an important intermediary step in relaying signals vital for cellular homeostasis and energy metabolism.
Researchers have associated { 'ARL2' } with neurodegenerative diseases such as Charcot-Marie-Tooth disease type 2A. This association stems from its interaction with mitofusin 2 a protein critical for mitochondrial fusion. Additionally abnormalities in ARL2 expression have implications for certain cancers as disrupted microtubule dynamics can lead to unchecked cell division. Understanding these associations provides insights into the potential for ARL2 as a therapeutic target in disease treatment.