Abcam, ab250785, Anti-hnRNP Q antibody [EPR15096] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal hnRNP Q antibody. Carrier free. Suitable for IHC-P, ICC/IF, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15096,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250785 is the carrier-free version of
ab184946
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) also known as SYNCRIP or NSAP1 plays an important mechanical role in RNA metabolism. This protein has a mass of approximately 65 kDa and is expressed in a wide range of tissues with significant presence in the cytoplasm and nucleoplasm. hnRNP Q binds to RNA and participates in processes like mRNA splicing transport stabilization and translation regulation. It interacts with distinct RNA sequences influencing gene expression patterns important for cellular function.
Biological function summary
HnRNP Q is involved in various cellular processes and contributes to the post-transcriptional regulation of mRNA. It often forms part of ribonucleoprotein complexes where it modifies RNA molecule processing and stability. This interaction ensures proper translation and adaptation to the cell's needs. hnRNP Q's action is essential for neuronal development and synaptic plasticity highlighting its functional importance in the nervous system.
Pathways
HnRNP Q engages in targeted pathways to influence cellular signaling and gene expression. It plays a role in the mTOR signaling pathway pivotal for cell growth and metabolic regulation. Through this pathway hnRNP Q associates with proteins like mTOR and RAPTOR which aid in nutrient sensitivity adaptation. Additionally it contributes to the mRNA surveillance pathways ensuring the maintenance of RNA quality control mechanisms in the cell.
HnRNP Q shows a significant relationship with neurodegenerative diseases and cancer. Alterations in its expression or function associate with disorders like Amyotrophic Lateral Sclerosis (ALS) and various carcinomas. For instance changes in hnRNP Q levels can influence the cellular management of stress responses and apoptosis often via interactions with proteins like TDP-43 and FUS which are implicated in ALS pathogenesis. Additionally upregulation of hnRNP Q in certain cancers has been linked to increased tumorigenic potential and altered cellular metabolism suggesting its potential as a therapeutic target.