Abcam, ab250918, Anti-Retinoic Acid Receptor gamma antibody [EPR2020(N)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal RARG antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2020(N),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250918 is the carrier-free version of
ab187159
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Retinoic Acid Receptor gamma (RARγ) also known as NR1B3 is a nuclear receptor that mediates the actions of retinoic acid. This receptor has a molecular mass of approximately 50 kDa. Scientists commonly find RARγ in a variety of tissues including the skin lung and central nervous system. The receptor functions as a transcription factor by binding to specific DNA sequences and regulating the expression of genes involved in cellular proliferation and differentiation.
Biological function summary
RARγ plays an essential role in modulating gene expression in response to retinoic acid. This receptor forms heterodimeric complexes with retinoid X receptors (RXRs) to initiate transcriptional activation. RARγ part of the nuclear receptor superfamily drives processes such as embryogenesis and cell differentiation by controlling gene networks. Its presence is necessary for proper functioning in many physiological contexts contributing to homeostasis and development.
Pathways
Retinoic acid signaling involves RARγ and plays a pivotal role in the retinoic acid signaling pathway and the Wnt signaling pathway. RARγ interacts with proteins like RXRs to regulate gene transcription necessary for cell fate decisions and tissue patterning. These pathways link to key cellular processes highlighting the importance of RARγ in transcriptional regulation and cellular development.
RARγ has associations with skin disorders such as psoriasis and certain types of cancer including acute promyelocytic leukemia. Disruptions in retinoic acid signaling implicate this receptor in abnormal cell proliferation and differentiation. In leukemia the receptor partners with RXRs and interacts with fusion proteins like PML-RARα to drive cancerous processes. Understanding RARγ and its interactions contributes to developing treatments targeting these disease mechanisms.