Abcam, ab251088, Anti-SEC24D antibody [EPR16089] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal SEC24D antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16089,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251088 is the carrier-free version of
ab191566
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SEC24D also known as SEC24-related protein D plays an important role in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus by mediating cargo selection for vesicle budding. This protein is part of the COPII coat complex. SEC24D has a molecular mass of approximately 130 kDa. It is widely expressed in most tissues with higher expression levels observed in the liver and testes. Its function in vesicular trafficking makes it essential for maintaining cellular protein transport.
Biological function summary
The protein is involved in the packaging of cargo into COPII vesicles. It operates within the COPII complex which includes proteins like SEC23 SEC13 SEC31 and SAR1. SEC24D functions by recognizing and binding specific cargo sorting signals ensuring proteins reach their correct destination. This process is fundamental in maintaining proper cellular organization and function by facilitating efficient secretory pathways.
Pathways
The SEC24D protein is important in the secretory pathway one of two key pathways for protein transport. It collaborates with the COPII machinery linking endoplasmic reticulum export to various cellular functions. SEC24D works closely with SEC23 in forming budding vesicles which eventually fuse with the Golgi apparatus. The COPII pathway is tightly connected with the ER stress response pathway ensuring cellular adaptation to changes in protein-folding demands.
SEC24D mutations have been linked to congenital disorders of glycosylation and skeletal abnormalities such as osteogenesis imperfecta. SEC24D interacts with other components of the COPII complex like SEC23 which also play a role in these conditions. Understanding the function of SEC24D can provide insights into therapeutic strategies aimed at correcting dysregulated protein trafficking pathways associated with such disorders.