Abcam, ab251097, Anti-SLP-2 antibody [EPR18718] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal SLP-2 antibody. Carrier free. Suitable for ICC/IF, IP, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18718,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), IP, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251097 is the carrier-free version of
ab191883
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLP-2 also known as stomatin-like protein 2 is a protein with a mass of approximately 38 kDa. It is widely expressed in different tissues with high presence in mitochondrial inner membrane domains. This protein belongs to the stomatin protein family and possesses functions related to cellular compartmentalization and stability.
Biological function summary
Stomatin-like protein 2 is integral to maintaining mitochondrial morphology and function. It is closely involved in regulating mitochondrial membrane potential and apoptosis. As part of a multiprotein complex SLP-2 helps in organizing lipid and protein microdomains which are important for various mitochondrial processes and cellular energy dynamics.
Pathways
Stomatin-like protein 2 contributes significantly to the oxidative phosphorylation and apoptosis pathways. It interacts with proteins such as prohibitins which are critical in maintaining mitochondria integrity and function. These interactions highlight SLP-2's role in both energy production and programmed cell death highlighting its significance in cellular metabolic regulation and stress response.
Stomatin-like protein 2 has been linked to cancer and cardiovascular disorders. Its up-regulation is often observed in various cancers suggesting a role in tumorigenesis by affecting the cellular energy balance and mitochondrial dynamics. The protein also connects to cardiolipin a lipid implicated in heart diseases illustrating its involvement in cardiovascular conditions through mitochondrial dysfunction.