Abcam, ab251108, Anti-TSSK2 antibody [EPR16116] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TSSK2 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16116,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251108 is the carrier-free version of
ab192026
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Testis-specific serine/threonine kinase 2 commonly known as TSSK2 is a serine/threonine protein kinase with a molecular weight of approximately 42 kDa. TSSK2 is predominantly expressed in testicular tissue where it plays an essential role in sperm development. The protein is characterized by a kinase domain that is important for its activity allowing it to transfer a phosphate group from ATP to serine/threonine residues on substrate proteins which affects their function and activity.
Biological function summary
The function of TSSK2 extends to supporting the process of spermatogenesis. It actively participates in sperm differentiation and maturation. TSSK2 does not typically form part of any larger protein complex but acts as an individual molecule with indispensable roles in sperm cell structure formation. Through its kinase activity it modifies other proteins critical for the development of functional sperm indicating its significant contribution to male fertility.
Pathways
TSSK2 engages in the meiosis and spermatogenesis pathways serving a purpose in cellular processes that are fundamental for male germ cell development. It interacts with proteins such as HSP90 a chaperone protein which assists in the folding and function of various protein kinases during sperm production. TSSK2's actions within these pathways highlight its functional relevance and linkage to essential reproductive processes.
TSSK2 shows known associations with male infertility particularly cases characterized by failure in sperm production or maturation. Its malfunction or deficiency can compromise spermatogenesis which may relate back to defective kinase activity. Furthermore TSSK2 interplays with other proteins such as CK2 another kinase which also impacts fertility highlighting the broader network of interactions in which TSSK2 participates. Understanding these associations provides insight into potential therapeutic targets for infertility.