Abcam, ab251138, Anti-RIMS3 antibody [EPR10117(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal RIMS3 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10117(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251138 is the carrier-free version of
ab192602
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RIMS3 also known as Regulating Synaptic Membrane Exocytosis 3 is a protein around 170 kDa in size. It plays a role in the modulation of synaptic vesicle exocytosis. RIMS3 is expressed mainly in neuronal tissues and shows localization at presynaptic active zones. This protein is part of the Rab3-interacting molecule family which contributes to the intricate machinery involved in neurotransmitter release at synapses by interacting with other proteins important for synaptic transmission.
Biological function summary
The function of RIMS3 revolves around its role in synaptic processes. RIMS3 contributes to the regulation of synaptic vesicle priming and neurotransmitter release. It functions as part of a protein complex that includes other synaptic proteins like Munc13 and RIM-binding protein. These interactions stabilize synaptic transmission and maintain precise communication between neurons. The absence or alteration of RIMS3 can disrupt these processes and result in altered synaptic strength and plasticity.
Pathways
RIMS3 participates in synaptic vesicle cycle and neurotransmitter release pathways. It interacts with members of the Rab family such as Rab3 playing a part in the vesicle docking and priming steps critical for synaptic activity. Through these pathways RIMS3 aligns functionally with related proteins like Synaptotagmin and SNARE complex components amplifying the efficiency of synaptic vesicle release which underpins neuronal communication and network activity.
Alterations in RIMS3 expression associate with neurological conditions such as autism spectrum disorder (ASD) and schizophrenia. Mutations or disruptions in RIMS3 or its related pathways can affect synaptic efficiency contributing to these disorders. Other synaptic proteins like Neurexin and Neuroligin also connect to these synaptic deficits reinforcing the link between proper RIMS3 function and neural health. Understanding the precise involvement of RIMS3 in these diseases may guide therapeutic approaches aimed at restoring normal synaptic function.