Abcam, ab251155, Anti-ART3 antibody [EPR7220(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ART3 antibody. Carrier free. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7220(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251155 is the carrier-free version of
ab192870
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ART3 also known as ADP-ribosyltransferase 3 is an enzyme with a molecular mass of approximately 41 kDa. It belongs to the family of ARTs (ADP-ribosyltransferases) which facilitate the transfer of ADP-ribose from NAD+ to target proteins modifying their function. ART3 is mainly expressed on the surface of cells with higher expression observed in testicular tissues. Its distribution suggests a specialized role in certain physiological processes.
Biological function summary
ART3 modifies protein functions by adding ADP-ribose groups a process important for cellular signaling and protein interactions. While it is not as deeply investigated as other ART family members ART3 still plays significant roles in certain biological contexts. It operates independently rather than being part of a larger complex. Current research explores its involvement in sperm maturation and other reproductive functions especially due to its elevated expression in testicular tissue.
Pathways
ART3's actions integrate into the wider cellular signaling network influenced by ADP-ribosylation. This modification impacts pathways such as cell communication and possibly apoptosis although detailed mapping in these contexts remains developing. ART3 shares mechanistic similarities with proteins such as ART1 and ART5 which also perform ADP-ribosylation and align with changes in protein activity and signaling dynamics.
ART3 has potential implications in reproductive health and certain cancers. Altered ART3 expression or function may link to testes-related disorders or contribute to cellular oncogenesis. It connects with other proteins like ART1 whose dysregulation has been studied in various cancers. Understanding ART3's contributions could aid in developing targeted treatments or diagnostics related to its roles in these diseases.