Abcam, ab251234, Anti-Sts1 antibody [EPR16980] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Sts1 antibody. Carrier free. Suitable for ICC/IF, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16980,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251234 is the carrier-free version of
ab197027
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sts1 also known as Suppressor of T-cell receptor signaling 1 is a protein with a mass of approximately 72 kDa. It functions mechanically by serving as a negative regulator in T-cell receptor signaling pathways. Sts1 contains N-terminal SH3 domains and C-terminal ubiquitin-associated domains essential for its regulatory activity. Expression of Sts1 is widespread with notable abundance in immune cells such as T-cells and B-cells. These structural features enable Sts1 to interact with various signaling molecules.
Biological function summary
In cellular processes Sts1 plays a role in modulating immune responses. It interacts with signaling proteins including the ZAP-70 kinase which is central to T-cell receptor signaling. Sts1 forms a complex with several proteins involved in the ubiquitination process which marks proteins for degradation or alters their function. By this Sts1 influences the strength and duration of signals received by the immune cells ensuring proper immune system function.
Pathways
Sts1 serves in the T-cell receptor signaling pathway and contributes to the modulation of the immune response. The protein is closely linked to ubiquitin-proteasome system pathways which govern protein turnover and cellular regulation. In these pathways Sts1 associates with proteins like c-Cbl which are involved in the ubiquitination and degradation of signaling intermediates.
Deficiencies or dysregulation of Sts1 are often associated with autoimmune diseases and certain lymphomas. Its interplay with proteins like c-Cbl or ZAP-70 can result in aberrant T-cell activation and uncontrolled proliferation. This abnormal signaling could lead to autoimmune disorders such as systemic lupus erythematosus or contribute to the development of B-cell lymphomas where immune regulation breaks down.