Abcam, ab251308, Anti-STARD4 antibody [EPR17847] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal STARD4 antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17847,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251308 is the carrier-free version of
ab200344
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STARD4 or StAR-related lipid transfer protein 4 is a cytosolic protein involved in cholesterol transport. It is approximately 22 kDa in size. This protein facilitates the shuttling of cholesterol between cellular membranes and the cytoplasm. Expression of STARD4 is found in various tissues but it is notably present in the liver and macrophages. Its role in these tissues supports overall cholesterol homeostasis by regulating intracellular cholesterol distribution.
Biological function summary
This protein participates in intracellular lipid trafficking as part of larger biosynthetic and regulatory processes. It does not function independently but rather interacts with several lipid-binding proteins to control cholesterol availability within the cell. These interactions are essential for maintaining membrane integrity and the synthesis of steroid hormones. The activity of STARD4 directly influences the regulation of lipid metabolism and energy homeostasis.
Pathways
STARD4 contributes to lipid metabolism and homeostasis pathways. It plays a role in the cholesterol transport pathway specifically in concert with proteins like STARD1 and STARD5 which also bind and transfer cholesterol. Its function ensures proper cholesterol distribution required for cellular signaling and membrane structure. The activity of STARD4 intersects with other proteins involved in these pathways such as apolipoproteins and other lipid-binding proteins to maintain lipid balance within tissues particularly in organs like the liver.
STARD4 is associated with conditions linked to cholesterol imbalance such as atherosclerosis and non-alcoholic fatty liver disease (NAFLD). Altered expression or function of STARD4 can disrupt normal cholesterol homeostasis contributing to the development of these disorders. Research indicates that its interactions with proteins such as low-density lipoprotein (LDL) receptors and apolipoprotein E (ApoE) are critical in understanding disease mechanisms. Modification in the function or expression of STARD4 can signify altered lipid transport and contribute to pathogenesis in related disorders.