Abcam, ab251372, Anti-RMS1 antibody [EPR20103] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal RMS1 antibody. Carrier free. Suitable for WB and reacts with Saccharomyces cerevisiae samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR20103,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Saccharomyces cerevisiae,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251372 is the carrier-free version of
ab202438
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RMS1 also known as Rhomboid-like protein is a transmembrane serine protease with a molecular mass of approximately 55 kDa. It locates primarily on the inner mitochondrial membrane and is widely expressed across various tissues including the heart brain and liver. RMS1 belongs to the family of rhomboid proteases which perform intramembrane proteolysis. This protease modulates protein processing by cleaving specific substrate proteins within the membrane environment influencing their function and stability.
Biological function summary
This protein contributes to cellular homeostasis by regulating protein quality control and mitochondrial function. It engages in the organized removal of misfolded or damaged proteins within the mitochondria working as part of multiprotein complexes. RMS1 plays a significant role in the control of a subset of substrates ensuring proteins are maintained in their functional forms or cleared if defective which is critical for cellular metabolism and overall energy production.
Pathways
RMS1 interacts with proteolytic and mitochondrial homeostasis pathways. It participates in a pathway linked with mitochondrial proteostasis closely interacting with other proteins like PARL and PINK1 to ensure mitochondrial quality control. RMS1's proteolytic activity adjusts the protein components within the mitochondria aligning with the cell's metabolic demands and signaling needs which is vital for cell survival and adaptation to stress.
Defects or dysregulation of RMS1 have been linked to neurodegenerative conditions such as Parkinson's disease. RMS1 affects and connects with other key proteins involved in these disorders including DJ-1 and PINK1 which are vital for maintaining mitochondrial health. Aberrant function of RMS1 disrupts the meticulously balanced environment of protein turnover in mitochondria leading to the accumulation of harmful protein aggregates and oxidative stress which contributes to neuronal cell death.