Abcam, ab251461, Anti-BTG4 antibody [EPRZJU-21] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal BTG4 antibody. Carrier free. Suitable for ICC/IF, IP, WB and reacts with Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPRZJU-21,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse,
Applications:IP, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:We have not been able to detect the endogenous mouse BTG4 with this antibody.

Product details:
ab251461 is the carrier-free version of
ab206914
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BTG4 also known as B-cell translocation gene 4 is a protein with a molecular mass of approximately 26 kDa. This protein is part of the BTG/Tob family which is involved in cell growth regulation. BTG4 is expressed predominantly in testicular tissue where it plays a role in germ cell development. Researchers also find it in lower amounts in other tissues such as the brain and ovary indicating a broader but less pronounced expression profile.
Biological function summary
BTG4 associates with several cellular processes including cell cycle regulation and transcriptional control. It does not operate as an isolated unit but forms complexes with elements like protein arginine methyltransferase suggesting functions in post-translational modifications. BTG4 influences mRNA deadenylation impacting mRNA stability and translation rates processes critical for cellular and developmental adjustments.
Pathways
BTG4 plays a role in the cell cycle and mRNA degradation pathways. Its interaction with proteins like cyclin B1 and Cdc2 highlights its position in the regulation of cellular proliferation and division cycles. As part of these pathways BTG4 modulates key transitions in the cell cycle that ensure proper cellular functions and development.
Disruption in BTG4 expression associates with infertility and certain cancers particularly testicular cancer. This relationship suggests BTG4's involvement in germ cell regulation failures. The association with proteins such as p53 in cancer pathways also illustrates its potential role in tumorigenesis through the influence on cell cycle checkpoints and apoptotic processes.