Abcam, ab251518, Anti-ITLN1+ITLN2 antibody [EPR20311] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ITLN1 antibody. Carrier free. Suitable for WB, IHC-Fr, IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR20311,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:IHC-Fr, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ITLN1 mRNA expression in stomach has been reported [PMID: 19549487]. Another report [PMID: 22768319] shows no staining on stomach at protein level. In our hands this antibody showed weak cytoplasmic staining on stomach samples.

Product details:
ab251518 is the carrier-free version of
ab210483
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ITLN1 and ITLN2 also known as intelectin-1 and intelectin-2 are carbohydrate-binding proteins. ITLN1 has a molecular mass approximately 35 kDa while ITLN2 is similar in size. Both proteins are mainly expressed in human adipose tissue small intestine and the respiratory tract. These proteins have a significant presence in epithelial cells and are secreted as part of the extracellular matrix. They belong to the lectin family and recognize galactofuranose-containing glycans in microorganisms.
Biological function summary
Intelectins modulate immune responses and have been identified in promoting microbial defense. They are known for their role in binding specific sugars and facilitating the neutralization of pathogens. ITLN1 and ITLN2 do not form a complex but share functional similarities in immune surveillance. Their activity contributes to interactions with lipid metabolism and insulin signaling influencing glucose homeostasis and inflammation regulation.
Pathways
Intelectins integrate with the immune response pathway and insulin signaling pathway. They influence immune system activation by recognizing carbohydrate structures unique to microorganisms. The proteins interact with immune molecules like complement proteins and play supportive roles in the insulin signaling cascade linking them to proteins such as GLUT4 and IRS-1. Their functions promote the maintenance of metabolic balance and protect against microbial infections.
ITLN1 and ITLN2 play roles in metabolic diseases and respiratory infections. In obesity dysregulation of ITLN1 links to altered insulin sensitivity associating the protein with adiponectin. In asthma differential expression of these proteins relates to inflammation and airway resistance connecting ITLN2 to interleukins. These associations highlight intelectins as potential biomarkers or therapeutic targets in metabolic and inflammatory conditions.