Abcam, ab251766, Anti-CAMSAP2 antibody

Size: 100µL
Rabbit Polyclonal CAMSAP2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CAMSAP2 aa 600-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CAMSAP2 aa 600-700. The exact immunogen used to generate this antibody is proprietary information.Q08AD1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CAMSAP2 also known as calmodulin-regulated spectrin-associated protein family member 2 is a microtubule-stabilizing protein with a molecular mass of approximately 198 kDa. It binds to the minus ends of microtubules stabilizing them and regulating their dynamics. CAMSAP2 is expressed in various tissues with a significant presence in neuronal tissue. The protein plays a vital role in stabilizing the microtubule network which influences cellular architecture and intracellular transport.
Biological function summary
The regulation of microtubule dynamics by CAMSAP2 ensures proper neuronal development and function. CAMSAP2 is part of a protein complex that is essential for maintaining microtubule integrity and organization. It interacts with other proteins such as CAMSAP1 and CAMSAP3 each playing distinct roles in microtubule arrangement. These interactions help in maintaining cellular structures which are necessary for processes like cellular division and differentiation.
Pathways
CAMSAP2 is involved in microtubule-associated pathways critical for cell stability and signaling. The protein is part of the axon guidance pathway where it functions alongside other proteins including PTEN and CRMP2 to ensure correct neural network formation. CAMSAP2 also engages in the regulation of cytoskeleton organization pathways where it collaborates with microtubule-associated proteins to support cellular morphology and dynamics.
CAMSAP2 plays a part in conditions affecting the nervous system such as neurodevelopmental disorders and certain neurodegenerative diseases. Mutations or dysregulation of CAMSAP2 have been linked to intellectual disabilities due to its role in neuronal structure and signaling. This protein also interacts with tau a protein commonly associated with neurodegenerative disorders like Alzheimer's disease suggesting a potential link between CAMSAP2 function and tauopathies.