Abcam, ab251774, Anti-OXR1 antibody

Size: 100µL
Rabbit Polyclonal OXR1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OXR1 aa 250-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human OXR1 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.Q8N573

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OXR1 also known as Oxidation Resistance 1 is a protein that plays a significant role in cellular defense against oxidative stress. It has a mass of approximately 87 kDa. OXR1 is widely expressed in human tissues with higher levels observed in the brain and liver. This protein localizes primarily in the mitochondria where it contributes to safeguarding cells by being part of the antioxidant defense system.
Biological function summary
OXR1 mitigates oxidative damage and enhances cell survival under stress conditions. It stimulates the expression of antioxidant enzymes including superoxide dismutase and catalase. OXR1 doesn't act alone but functions as part of a protective network to maintain cellular redox balance. Its role is important in neural tissues where oxidative stress can lead to severe damage.
Pathways
OXR1 engages in oxidative stress and mitochondrial homeostasis pathways. Its activity is linked to the antioxidant response elements and interacts with proteins like Nrf2 (Nuclear factor erythroid 2-related factor 2) which orchestrates the regulation of antioxidant proteins. By participating in these pathways OXR1 helps to modulate cellular responses to oxidative insults and contributes to maintaining cellular integrity.
OXR1 has been associated with neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. Altered function or expression of OXR1 can lead to increased oxidative damage exacerbating these conditions. OXR1's interaction with proteins such as Nrf2 indicates a connection to pathways that when dysregulated contribute to disease processes. Understanding the role of OXR1 in these disorders could offer insights into novel therapeutic strategies aimed at reducing oxidative damage.