Abcam, ab251804, Anti-TLX3 antibody

Size: 100µL
Rabbit Polyclonal TLX3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TLX3 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TLX3 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.O43711

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TLX3 also known as T-cell leukemia homeobox protein 3 is a transcription factor with a mass of approximately 33 kDa. It belongs to the homeobox gene family and plays a role in regulating gene expression. TLX3 shows expression mostly in the nervous system and immature T-cells particularly during development. The protein acts by binding to specific DNA sequences leading to activation or suppression of target genes essential for the control of developmental processes.
Biological function summary
TLX3 influences the fate of neuronal cell types and is critical in determining neurotransmitter identity. It functions as part of a regulatory complex that guides the differentiation of neurons especially in the dorsal spinal cord. Its activity impacts pathways that promote the production of excitatory glutamatergic neurons over inhibitory GABAergic neurons ensuring proper balance in the central nervous system.
Pathways
TLX3 operates in the gene regulatory networks connected to neuronal differentiation and survival. It interacts importantly with the Notch signaling pathway influencing neurogenesis and cell fate decisions. TLX3 shares regulatory pathways with proteins such as TLX1 and influences the expression of downstream genes that are required for neuronal identity and function. These interactions indicate its role in diverse neuronal processes.
TLX3 is linked to T-cell acute lymphoblastic leukemia (T-ALL) and has implications in certain neurodevelopmental disorders. In T-ALL overexpression of TLX3 disrupts normal T-cell development leading to malignancy. It interacts with proteins like TAL1 contributing to leukemogenesis through modulation of gene networks that control cell proliferation and differentiation. Additionally altered TLX3 expression may correlate with developmental issues in neural patterning showing its importance in both cancer and nervous system diseases.