Abcam, ab251864, Anti-NCAPG antibody

Size: 100µL
Rabbit Polyclonal NCAPG antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NCAPG aa 300-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NCAPG aa 300-450. The exact immunogen used to generate this antibody is proprietary information.Q9BPX3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Nucleolar and spindle-associated protein 1 (NCAPG) is a part of the condensin complex important for chromosome condensation during mitosis and meiosis. NCAPG also known as CAP-G has a mass of approximately 110 kiloDaltons. It expresses highly in proliferating cells like those in bone marrow and the spleen. Its presence is critical during the cell cycle especially in the subphase of G2/M transition.
Biological function summary
NCAPG plays a role in maintaining chromosome architecture and stability cooperating within the condensin complex. This complex is essential for proper chromosomal segregation during cell division. It acts by introducing supercoils into the DNA promoting compaction and organizing chromatin. Incorrect functioning of NCAPG can lead to aneuploidy.
Pathways
NCAPG is a part of key regulatory circuits such as the cell cycle progression and DNA replication pathways. It interacts with other structural proteins like SMC2 and SMC4 within these pathways. These interactions are vital for replicating genetic material accurately and ensuring the proper alignment of chromosomes before cell division occurs.
NCAPG associates with tumorigenesis and cancer progression. High expression levels of NCAPG have been observed in different cancers including hepatocellular carcinoma and colorectal cancer. In these contexts the protein may interact with other significant factors such as Cyclin B1. Abnormal NCAPG activity can potentially lead to increased cell proliferation and tumor growth due to its role in chromosome stability and cell division regulation.