Abcam, ab251869, Anti-Filensin antibody

Size: 100µL
Rabbit Polyclonal Filensin antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human BFSP1 aa 250-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human BFSP1 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.Q12934

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Filensin also known as beaded filament structural protein 1 (BFSP1) is a cytoskeletal intermediate filament protein. It plays a role in maintaining the structural integrity of cells. The molecular mass of Filensin is approximately 100 kDa. It expresses mainly in the lens fibers of the eye where it contributes to the unique architecture and function of the lens. In the lens Filensin interacts with other proteins to form a filament network important for maintaining lens transparency and flexibility.
Biological function summary
Filensin interacts with phakinin also called beaded filament structural protein 2 (BFSP2) forming a complex known as the beaded filament. This complex provides structural support to lens fiber cells essential for their long-term survival and functional maintenance. Filensin's role is vital for maintaining the mechanical properties and flexibility of lens cells ensuring the proper refractive function of the lens. Its expression and function are tightly regulated during lens development and differentiation.
Pathways
Filensin is part of the intermediate filament pathway influencing cell structure and mechanical stability. It associates with the cytoskeletal organization pathways playing a role in maintaining the shape and elasticity of lens fibers. Through these pathways Filensin interacts with proteins like vimentin and alpha-crystallin which are involved in maintaining lens cell integrity and preventing aggregation of lens proteins. These interactions are important for lens transparency and visual function.
Filensin mutations have been linked to cataracts a condition characterized by lens opacity leading to impaired vision. Mutations or dysfunctions in Filensin along with its partner phakinin disrupts the structural integrity of the lens causing cataract formation. Abnormalities in these proteins affect lens transparency and elasticity leading to progressive visual impairment. Studying these relationships provides insights into therapeutic targets for preventing or treating cataracts and related lens disorders.