Abcam, ab251875, Anti-PGRMC2 antibody

Size: 100µL
Rabbit Polyclonal PGRMC2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PGRMC2 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PGRMC2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O15173

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PGRMC2 also known as Membrane-Associated Progesterone Receptor Component 2 is a protein that plays several roles mechanically in the cell. This protein weighs approximately 22.5 kDa and exists across various tissues including liver adipose tissue and the central nervous system. It exists in cellular membranes where it may facilitate interaction with other cellular components. This specific positioning and distribution allow PGRMC2 to modulate various signaling pathways.
Biological function summary
PGRMC2 participates in multiple cellular processes related to cell survival and metabolism. It often functions as part of larger protein complexes and interacts with other proteins affecting mitochondrial function and steroid signaling. Its biological role includes influencing mitochondrial respiration and energy homeostasis critical processes in numerous cellular functions. Researchers have discovered that PGRMC2 interacts with heme impacting vital cellular and metabolic functions.
Pathways
PGRMC2 is active in steroid hormone signaling and cellular stress response pathways. It interacts with proteins like cytochrome P450 which is significant for the metabolism of various substances and heme oxygenase which regulates the degradation of heme. These interactions highlight PGRMC2's impact on vital pathways involved in maintaining cellular stability and response mechanisms.
Researchers link PGRMC2 to metabolic conditions such as obesity and diabetes. It plays a role in lipid metabolism and energy balance both critical factors in the development of these conditions. Furthermore PGRMC2 interaction with insulin receptor substrates suggests a connection to insulin resistance a common feature of type II diabetes. Understanding PGRMC2's function and its related proteins offers potential insights into therapeutic targets for these conditions.