Abcam, ab251903, Anti-USP32 antibody

Size: 100µL
Rabbit Polyclonal USP32 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human USP32 aa 400-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human USP32 aa 400-600. The exact immunogen used to generate this antibody is proprietary information.Q8NFA0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
USP32 also known as Ubiquitin Specific Peptidase 32 is a deubiquitinating enzyme with a molecular mass of approximately 160 kDa. Its primary function involves removing ubiquitin moieties from target proteins regulating their stability and degradation. USP32 is expressed in various tissues including brain breast and colon. This expression pattern suggests that it has diverse roles in multiple physiological contexts.
Biological function summary
Removing ubiquitin by USP32 affects protein degradation and intracellular signaling. It does not operate as part of a complex functioning independently to maintain protein homeostasis. This activity impacts several cellular processes such as cell cycle regulation and signaling pathways where careful timing and control of protein degradation are essential.
Pathways
USP32 directly influences the ubiquitin-proteasome system which maintains protein quality and regulates turnover of key signaling proteins. It participates in pathways involving WNT signaling interacting with proteins such as β-catenin to modulate processes like cell proliferation and differentiation. Through these pathways USP32 supports cellular functions that are essential for homeostasis.
Dysregulation in USP32 function can link to cancer and neurodegenerative diseases. In cancer USP32's association with the WNT signaling pathway connects it to abnormal cell growth particularly in breast cancer often interacting with proteins like APC. In neurodegenerative disorders its role in protein homeostasis implies connections to Alzheimer’s disease where it may affect the processing of amyloid precursor protein linking it to proteins involved in plaque formation and neuronal loss.