Abcam, ab253000, Anti-TM9SF4 antibody

Size: 100µL
Rabbit Polyclonal TM9SF4 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TM9SF4 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TM9SF4 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q92544

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TM9SF4 also known as Transmembrane 9 Superfamily Member 4 is a multi-pass membrane protein with an approximate molecular mass of 70 kDa. It is localized in the Golgi apparatus and endosomes showing a notable expression in immune-related cells such as macrophages and dendritic cells. TM9SF4 is involved in the transport and sorting of proteins within cellular compartments playing an important role in maintaining intracellular pH homeostasis by modulating ion exchange across membranes.
Biological function summary
As part of a larger protein family TM9SF4 is involved in the regulation of cellular processes like endocytosis and exocytosis. It functions as a regulator of phagocytosis a process critical for immune response and cell clearance. Through its action in cellular compartments it contributes to antigen presentation thereby influencing cellular immune responses. Its involvement in these pathways highlights its significance in both normal cellular functions and immune system regulation.
Pathways
TM9SF4 influences processes associated with the endocytic pathway and vesicular trafficking. It interacts within cellular networks involving SNARE proteins responsible for vesicle fusion highlighting its role in transport pathways. TM9SF4 also associates with V-ATPase complexes affecting acidic environments necessary for hydrolytic enzymes in endosomes. Through these connections TM9SF4 helps sustain cellular dynamics and integrity.
TM9SF4 links to immune-related conditions particularly chronic inflammatory diseases. It affects macrophage function and inflammation making it relevant in disorders such as rheumatoid arthritis. Additionally TM9SF4 alterations associate with tumor microenvironments influencing cancer progression. Through its modulation of phagocytic functions abnormalities in TM9SF4 activity can alter interactions with proteins like TNF-alpha which are important in inflammation and cancer-related pathways.