Abcam, ab254255, Anti-SerpinB3/SCCA + SerpinB4/SCCA-2 antibody [EPR22455-57]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SerpinB3/SCCA antibody. Suitable for WB, IHC-P and reacts with Human, Recombinant fragment - Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22455-57,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SerpinB3 also known as Squamous Cell Carcinoma Antigen-1 (SCCA-1) and SerpinB4 or SCCA-2 belong to the serpin family of proteins. These proteins operate as intracellular protease inhibitors. They play a role in regulating the proteolytic activities within cells. SerpinB3 has a molecular mass of approximately 45 kDa while SerpinB4 is slightly larger around 49 kDa. You will find these proteins primarily expressed in normal squamous epithelium and tissues such as the skin lung and liver.
Biological function summary
Serpins act as inhibitors of serine proteases preventing unwanted proteolysis that could lead to cellular damage. They interact with various proteases to control processes like inflammation immune response and apoptosis. These proteins do not typically form part of a larger multi-protein complex but exert their effects individually within the cell. Their regulation of proteases helps maintain cellular function and structural integrity.
Pathways
Serpins interact within inflammation and apoptosis pathways. In the inflammatory pathway their inhibitory action on proteases helps modulate the inflammatory response. In apoptosis SerpinB3 can regulate proteases involved in cell death helping control cellular turnover. They relate to other proteins such as cathepsins and caspases through these pathways playing a part in keeping a balance between cell survival and death.
SerpinB3 and SerpinB4 closely associate with various cancers especially squamous cell carcinomas where their expression often increases. This elevated expression can help tumor cells evade apoptosis. Additionally they relate to chronic liver diseases such as liver fibrosis where they might contribute to disease progression through their ability to inhibit apoptosis. These proteins are connected to other markers of these conditions like alpha-fetoprotein in liver disease and can serve as potential biomarkers or therapeutic targets.