Abcam, ab254318, SIS3, Smad3 inhibitor

Size: 1mg / 5mg
MW 490 Da, Purity >98%. Potent and selective Smad3 inhibitor. Selectively inhibits TGF-beta 1/ALK5-induced Smad3 phosphorylation. Inhibits the TGF-beta 1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site. Has no effect on Smad2, p38, MAPK, ERK or PI 3-kinase signaling.
Key facts
CAS number:521984-48-5,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:490 Da,
Molecular formula:C28H28ClN3O3,
PubChem:16079005,
Nature:Synthetic,
Solubility:Soluble in DMSO to >25 mM,
Biochemical name:Sis3 HCl,
Biological description:Potent and selective Smad3 inhibitor. Selectively inhibits TGF-beta 1/ALK5-induced Smad3 phosphorylation. Inhibits the TGF-beta 1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site. Has no effect on Smad2, p38, MAPK, ERK or PI 3-kinase signaling.,
Canonical smiles:CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl,
Isomeric smiles:CN1C(=C(C2=C1N=CC=C2)/C=C/C(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl,
InChi:InChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;,
InChiKey:CDKIEBFIMCSCBB-CALJPSDSSA-N,
IUPAC Name:(E)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2227 Smad3 Inhibitor, SIS3. 2227-1 is the same size as the 5 mg size of ab254318.
Protect from light and moisture.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions