Abcam, ab254395, GSK872, Necroptosis inhibitor

Size: 5mg / 25mg
MW 383.5 Da, Purity >98%. Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury *in vivo*. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death *in vitro.*.
Key facts
CAS number:1346546-69-7,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:383.5 Da,
Molecular formula:C19H17N3O2S2,
PubChem:54674134,
Nature:Synthetic,
Solubility:Soluble in DMSO up to 50mM,
Biochemical name:N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine,
Biological description:Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury *in vivo*. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death *in vitro.*,
Canonical smiles:CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4,
InChi:InChI=1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22),
InChiKey:ZCDBTQNFAPKACC-UHFFFAOYSA-N,
IUPAC Name:N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine

Product details:
Solutions in DMSO can be stored for up to 1 month.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-The product can be stored for up to 12 months