Abcam, ab254448, Galunisertib (LY2157299), TGFB kinase antagonist

Size: 5mg / 10mg
MW 369.4 Da, Purity >98%. Highly potent, TGF-beta kinase (ALK5) inhibitor (IC 50 = 56 nM). Downregulates Smad2 phosphorylation. Increases VEGF-induced HUVEC cell migration. Enhances anti-neuroblastoma activity of Dinuxtuximab (anti-GD2 antibody) with natural killer cells. Reverses supression of human T cell proliferation induced by TGF-beta and regulatory T cells. Improves tumour growth inhibition and regression in colon carcinoma models. ALK4 and ALK5 (TGFβRI) inhibitor; component of growth media for urothelial organoids.
Key facts
CAS number:700874-72-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:369.4 Da,
Molecular formula:C22H19N5O,
PubChem:10090485,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:Galunisertib,
Biological description:Highly potent, TGF-beta kinase (ALK5) inhibitor (IC50 = 56 nM). Downregulates Smad2 phosphorylation. Increases VEGF-induced HUVEC cell migration. Enhances anti-neuroblastoma activity of Dinuxtuximab (anti-GD2 antibody) with natural killer cells. Reverses supression of human T cell proliferation induced by TGF-beta and regulatory T cells. Improves tumour growth inhibition and regression in colon carcinoma models. ALK4 and ALK5 (TGFβRI) inhibitor; component of growth media for urothelial organoids.,
Canonical smiles:CC1=NC(=CC=C1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N,
InChi:InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28),
InChiKey:IVRXNBXKWIJUQB-UHFFFAOYSA-N,
IUPAC Name:4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide

Product details:
Solutions in DMSO may be stored at -20°C for up to 1 month.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions