Abcam, ab254600, Anti-RSU1 antibody

Size: 100µL
Rabbit Polyclonal RSU1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Rat, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RSU1 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RSU1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q15404

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The RSU1 protein also referred to as Ras suppressor protein 1 is an influential regulator of cell adhesion and migration. It has a molecular mass of approximately 33 kDa. RSU1 mainly expresses in the brain and other tissues where it participates in various signaling pathways. The protein interfaces with integrin-linked kinase (ILK) and modulates actin cytoskeleton organization impacting cellular motility and interactions with the extracellular environment.
Biological function summary
The RSU1 protein integrates into a complex alongside ILK and other partners to affect cytoskeletal dynamics. It impacts cellular processes such as spreading adhesion and migration by modulating focal adhesion structures. RSU1 balances signaling cascades that influence cellular tension and stability contributing to cellular responses to external signals. This involvement makes RSU1 a notable player in maintaining cellular architecture and function.
Pathways
Involvement of RSU1 in the integrin and Rac1 signaling pathways highlights its functional roles. Through its interaction with ILK and p21-activated kinase (PAK) RSU1 regulates important steps in these pathways. The integration of RSU1 into these pathways underlines its contribution to cell shape modulation and movement emphasizing its role in normal cellular processes and homeostasis.
RSU1 research connects it with cancer progression and neurodegenerative diseases. Its dysregulation associates with altered cell migration and adhesion which are critical in cancer metastasis. RSU1 also engages with proteins like ILK which are implicated in tumorigenic pathways. In neurodegenerative contexts altered RSU1 expression patterns might affect neuronal structure and function linking it to conditions like Alzheimer's disease where cellular adhesion and cytoskeletal integrity are compromised.