Abcam, ab254661, Anti-KAT2/AadAT antibody

Size: 100µL
Rabbit Polyclonal KAT2/AadAT antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AADAT aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AADAT aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q8N5Z0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KAT2 also known as AadAT is an important lysine acetyltransferase enzyme that modifies proteins by adding acetyl groups to lysine residues. This process impacts several cellular functions. KAT2 typically features a molecular mass of approximately 55 kDa. You will usually find it expressed in a wide range of tissues including liver and brain. The enzyme's presence suggests an essential role in numerous physiological processes particularly within the nucleus where it modifies histones.
Biological function summary
KAT2/AadAT takes part in chromatin remodeling and gene expression regulation. This enzyme often functions as part of multiprotein complexes which include transcription factors and coactivators. The acetylation of histone proteins by KAT2 modifies chromatin structure resulting in enhanced access of transcription machinery to DNA. This activity is essential for processes like cell growth and differentiation playing a significant role in maintaining normal physiological conditions.
Pathways
KAT2/AadAT is integrated into the larger network of acetylation-mediated gene regulation. Two primary pathways it is involved with include the gene expression pathway and the chromatin modification pathway. In these pathways KAT2 interacts with proteins such as CBP/p300 which act as transcriptional coactivators. This interaction helps facilitate the acetylation process that is vital for gene activation and the subsequent biological responses to external stimuli.
Alterations in KAT2/AadAT activity link to specific conditions including cancer and neurodegenerative diseases. For instance abnormal KAT2 activity has been observed in certain cancers where dysregulated gene expression promotes tumor progression. Additionally altered acetylation patterns by KAT2 can contribute to neurodegenerative disorders where the modified interaction with proteins like HDAC1 disrupts normal neuronal function.