Abcam, ab254662, Anti-NPAS3 antibody

Size: 100µL
Rabbit Polyclonal NPAS3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human NPAS3 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NPAS3 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q8IXF0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NPAS3 also known as Neuronal PAS domain protein 3 is a transcription factor with a mass of approximately 105 kDa. It contains basic helix-loop-helix (bHLH) DNA-binding domains and PAS domains. NPAS3 expresses mainly in the brain indicating its involvement in neurological functions. This protein acts by regulating the transcription of specific genes necessary for brain development and function.
Biological function summary
NPAS3 influences brain development and synaptic plasticity. It forms part of a transcriptional complex with other cofactors that regulates gene expression important for neurological development. NPAS3 interacts with components in the brain's signaling pathways affecting neuronal growth and responses. The protein plays a significant role in processes like neurogenesis and the maintenance of neuronal circuitry.
Pathways
NPAS3 interacts with critical signaling pathways involved in neurological development such as the Wnt signaling pathway and Notch signaling pathway. The protein serves functions in the neuronal development stage by coordinating with other pathway proteins such as β-catenin in the Wnt signaling. NPAS3 modifies transcription rates of genes involved in these pathways impacting overall brain function and development.
NPAS3 associates with psychiatric conditions and developmental disorders such as schizophrenia and bipolar disorder. Alterations in NPAS3 function or mutation have shown links with these disorders. The protein interacts with DISC1 (Disrupted-In-Schizophrenia 1) and may influence or modify its role in disease mechanisms. Understanding NPAS3's involvement can help in identifying potential therapeutic targets for neurological and psychiatric conditions.