Abcam, ab254670, Anti-RPS21 antibody

Size: 100µL
Rabbit Polyclonal RPS21 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Rat, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RPS21 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RPS21 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P63220

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPS21 also known as Ribosomal Protein S21 is a component of the 40S small ribosomal subunit. It has a molecular mass of approximately 9.5 kDa. RPS21 is involved in the assembly and stability of ribosomal RNA. It is mostly expressed in the cytoplasm where it participates in the synthesis of proteins. Its expression levels vary between different cell types with significant presence in cells experiencing high rates of protein synthesis.
Biological function summary
The protein plays an important role as a structural constituent of ribosomes contributing to the translation process. It forms part of the ribosomal protein complex which is essential for ribosome biogenesis and function. The stability and functionality of the ribosomal protein complex rely on the presence of RPS21 affecting the overall efficiency of the protein translation machinery. This process is critical for normal cellular growth and division.
Pathways
The ribosome biogenesis and translation pathways are directly impacted by RPS21. It interacts closely with other ribosomal proteins and factors such as RPL5 and EIF4E. These interactions ensure the proper assembly of ribosomes and the initiation of translation. By playing an integral part in these pathways RPS21 influences cellular processes like cell growth maintenance and division.
Aberrations in RPS21 function associate with conditions such as Diamond-Blackfan anemia and certain cancers. Mutations or dysregulation affecting RPS21 can impact protein synthesis leading to these conditions. Other ribosomal proteins such as RPL11 and RPL35 also show involvement in these diseases suggesting a complex interaction network between ribosomal components in pathological states. Understanding RPS21's role in these diseases provides valuable insight into potential therapeutic interventions.