Abcam, ab254690, Anti-ANKS1A antibody

Size: 100µL
Rabbit Polyclonal ANKS1A antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ANKS1A aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ANKS1A aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q92625

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ANKS1A also known as Ankyrin Repeat and Sterile Alpha Motif Domain-Containing Protein 1A exhibits mechanical functions associated with signal transduction and protein-protein interactions. The protein possesses a molecular mass of approximately 186 kDa and can be detected throughout various tissues with stronger expressions noted in the brain. ANKS1A serves as an adapter molecule through its ankyrin repeat domains and SAM domain necessitating its role in cellular scaffolding.
Biological function summary
ANKS1A contributes to the regulation of Src family kinases which are pivotal in transmitting signals from various receptors on the cell's surface to the inside. It often acts as a part of a protein complex that includes the epidermal growth factor receptor (EGFR). This involvement suggests its importance in cell growth and differentiation processes. Modulating these kinases ANKS1A becomes significant in cellular responses to environmental stimuli influencing proliferation and survival.
Pathways
The involvement of ANKS1A spans the EGF signaling pathway linking its biological function to critical cellular signaling networks. In association with EGFR ANKS1A affects downstream signaling components such as MAPK and PI3K/AKT pathways integral for controlling cellular proliferation and survival. The protein functionally relates to other proteins like Cbl which mediate degradative pathways and modulate receptor signaling intensity reinforcing its regulatory impact.
ANKS1A holds relevance primarily to cancers and may contribute to neurodegenerative disorders. In cancer ANKS1A’s interaction with EGFR suggests a potential role in tumor growth through aberrant signaling pathways. Connections with proteins such as α-synuclein in neurodegenerative disorders hint at its possible involvement in disease progression impacting synaptic transmission and neuron stability. Understanding the dynamics of ANKS1A may provide insights into these complex disease mechanisms.