Abcam, ab254788, Anti-LHPP antibody

Size: 100µL
Rabbit Polyclonal LHPP antibody. Suitable for IHC-P, ICC/IF, WB and reacts with Human, Rat, Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Phospholysine phosphohistidine inorganic pyrophosphate phosphatase aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Phospholysine phosphohistidine inorganic pyrophosphate phosphatase aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H008

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The LHPP protein also known as phospholysine phosphohistidine inorganic pyrophosphate phosphatase serves as a histidine phosphatase. It has a molecular mass of approximately 29 kDa and is expressed in various tissues including the liver and brain. The protein catalyzes the hydrolysis of phosphoramidate bonds in specific substrates playing a role in cellular phosphate metabolism.
Biological function summary
LHPP acts on a complex network of phosphorylated molecules. This protein regulates intracellular phosphate levels impacting processes like energy production and signal transduction. LHPP is essential in controlling phosphorylation status affecting cellular functions such as growth and differentiation by interacting with substrates within the cell.
Pathways
LHPP participates in key biochemical routes like the phosphatidylinositol signaling pathway and possibly glycolysis. Within these pathways LHPP affects the activity of proteins like phosphatidylinositol-45-bisphosphate 3-kinase (PI3K) influencing cellular decision-making processes related to metabolism and survival. Understanding LHPP interactions aids in deciphering signal relay and metabolic adjustments in cells.
Alterations in LHPP expression associate with liver diseases and neurological disorders. In liver diseases an abnormality in phosphate metabolism could contribute to disease progression. In neurological contexts changes in LHPP or its pathway components may relate to diseases like epilepsy possibly through interactions with proteins affecting neuronal excitability such as voltage-gated ion channels. Connection of LHPP to these proteins highlights its significance in disease mechanisms.