Abcam, ab254831, Anti-XYLB antibody

Size: 100µL
Rabbit Polyclonal XYLB antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human XYLB aa 300-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human XYLB aa 300-450. The exact immunogen used to generate this antibody is proprietary information.O75191

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The XYLB protein also known as xylulose kinase plays a significant mechanical role in carbohydrate metabolism. It is a 57 kDa enzyme responsible for catalyzing the phosphorylation of xylulose a five-carbon sugar into xylulose-5-phosphate. This activity is important in the pentose phosphate pathway and is highly expressed in the liver kidney and intestine tissues where glucose and fructose metabolism primarily occur.
Biological function summary
Xylulose kinase contributes to the interconversion of carbohydrate molecules facilitating the utilization of xylose a sugar derived from plant biomass. While it does not directly function as part of a larger macromolecular complex XYLB supports the transformation of xylulose as part of the broader carbohydrate metabolic processes. It helps maintain a balance in energy metabolism and influences the flux of metabolites through various pathways in cells.
Pathways
Xylulose kinase is an important enzyme in the pentose phosphate pathway a pathway critical for nucleotide biosynthesis and antioxidant defense. This pathway interacts with glycolysis and is closely related to enzymes like transketolase and aldolase which further process sugar phosphates into energy-rich intermediates. XYLB's activity helps replenish metabolites into the glycolytic pathway connecting it to glucose metabolism and cellular respiration processes.
Alterations in XYLB activity have implications in metabolic disorders such as diabetes and obesity. Disrupted xylose metabolism can contribute to imbalances in sugar processing and energy utilization potentially exacerbating symptoms of these conditions. Research indicates a potential interaction between XYLB and glucose-6-phosphate dehydrogenase an enzyme whose dysfunction is relevant in metabolic syndrome highlighting bxyulose kinase's role in systemic carbohydrate management.