Abcam, ab254839, Anti-SERP1 antibody

Size: 100µL
Rabbit Polyclonal SERP1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SERP1 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SERP1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9Y6X1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Stress-Associated Endoplasmic Reticulum Protein 1 (SERP1) also known as Ribosome-Associated Membrane Protein 4 (RAMP4) performs important mechanical functions within the cell. With a mass of about 24 kDa SERP1 assists in the stabilization of newly synthesized polypeptides ensuring their proper folding and maturation within the endoplasmic reticulum. This protein is ubiquitously expressed in many tissues reflecting its broad role in maintaining cellular homeostasis.
Biological function summary
The function of SERP1 involves the interaction with ribosomes and the endoplasmic reticulum's membrane-associated components. SERP1 helps manage and support the correct folding of nascent proteins especially during cellular stress conditions. It does not form part of a larger protein complex but works closely with other stress response proteins to regulate protein synthesis integrity under adverse conditions.
Pathways
Stress response mechanisms and protein synthesis serve as essential biological contexts for SERP1's function. SERP1 is active in the endoplasmic reticulum stress response pathway helping mitigate misfolded protein accumulation during conditions such as unfolded protein response (UPR). It interacts with proteins like BiP/GRP78 which plays a part in these pathways coordinating a cell's adaptation to stress.
The malfunction of SERP1 impacts neurodegenerative diseases and metabolic disorders. Research links SERP1 to conditions such as Alzheimer's disease where inefficiencies in protein handling may worsen pathology. Moreover disruptions in SERP1 activity can associate with metabolic disorders like diabetes involving proteins such as PERK which participates in managing cellular stress responses similar to SERP1.