Abcam, ab254861, Anti-SCN3B antibody

Size: 100µL
Rabbit Polyclonal SCN3B antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SCN3B aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SCN3B aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9NY72

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCN3B also known as sodium channel beta-3 subunit or NaVβ3 is a protein component with a mass of approximately 21 kDa. It participates actively in the regulation of sodium ion channels which are essential for the transmission of electrical signals in the nervous system and heart. SCN3B is important for maintaining the proper functioning of various sodium channels by modulating their gating properties. It is mostly expressed in the central nervous system with significant presence noted in heart tissues. Its expression pattern suggests a role in areas requiring precise signal modulation.
Biological function summary
SCN3B influences the electrical excitability of neuronal and cardiac cells by serving as an auxiliary subunit of the voltage-gated sodium channels complex. It plays a supportive role by affecting the trafficking and functional integration of the alpha subunits which are key components for channel functionality. Through its involvement with these complexes SCN3B contributes to maintaining the balance and modulation of sodium ion flow across cell membranes which is critical for proper excitability in both neurons and myocytes.
Pathways
SCN3B's function integrates into pathways regulating electrical signaling in nerve and muscle tissues. Notably it participates in the cardiac action potential pathway ensuring that the rapid depolarization necessary for cardiac muscle contraction occurs effectively. It is also involved in the neuronal action potential signaling working closely with other proteins such as SCN1A and SCN5A which are alpha subunits of the sodium channels. These pathways highlight SCN3B's role in facilitating accurate and timely propagation of action potentials.
SCN3B abnormalities associate with conditions like Brugada syndrome and certain epileptic disorders. In Brugada syndrome a cardiac condition leading to sudden cardiac arrest SCN3B mutations can affect the sodium channels impairing signal conduction and increasing risk for arrhythmias. It has connections to SCN5A another sodium channel subunit implicated in similar cardiac disorders. For epilepsy disruptions in SCN3B can alter the excitability of neurons resulting in seizure development. By its association with key proteins SCN3B holds significant implications for understanding the molecular basis of these conditions.