Abcam, ab254965, Anti-PCGF3 antibody

Size: 100µL
Rabbit Polyclonal PCGF3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PCGF3 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PCGF3 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q3KNV8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PCGF3 also known as Polycomb Group RING Finger 3 is a protein that plays a mechanical role as part of the Polycomb group (PcG) proteins. The molecular mass of PCGF3 typically ranges around 35 kDa. It is expressed in various tissues with a notable presence in embryonic stem cells and during early developmental stages. PCGF3 functions as a component of Polycomb Repressive Complex 1 (PRC1) and influences chromatin modification impacting gene expression.
Biological function summary
PCGF3 influences gene silencing and epigenetic regulation. This protein forms part of the PRC1 complex which is important for maintaining the transcriptionally repressive state of many genes throughout development. PCGF3 alongside other PcG proteins helps to regulate chromatin structure by mediating the mono-ubiquitination of histone H2A one of its key functions in chromatin modification.
Pathways
The PCGF3 protein takes part in the Polycomb pathway which impacts the transcriptional silencing of Hox genes critical for body patterning and development. It relates closely to other proteins within this pathway such as BMI1 which is also a member of the PRC1 complex. Additionally PCGF3 plays a role in the regulation of the WNT signaling pathway influencing cellular differentiation and proliferation.
PCGF3 has links to various cancers and developmental disorders given its role in gene silencing and epigenetic regulation. Changes in its expression can lead to aberrant activation or repression of target genes potentially contributing to tumorigenesis. Research indicates that alterations in WNT signaling involving PCGF3 and related proteins such as RING1B could play a role in the pathogenesis of colorectal cancer and other malignancies.