Abcam, ab254973, Anti-AEBP1 antibody

Size: 100µL
Rabbit Polyclonal AEBP1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AEBP1 aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AEBP1 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q8IUX7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AEBP1 also known as Adipocyte Enhancer-Binding Protein 1 functions as a transcriptional repressor in the regulation of gene expression. AEBP1 has a molecular mass of approximately 160 kDa. This protein is expressed mainly in adipose tissues but researchers also find it in the brain lung and skeletal muscle suggesting a broader role in different tissues. AEBP1 contains a proline-rich domain and a DNA-binding domain which facilitate its function in the nucleus.
Biological function summary
AEBP1 influences functions associated with cellular proliferation and differentiation. The protein interacts with nuclear factor-kB (NF-kB) playing a significant role in immune response modulation. AEBP1 does not typically appear as part of a larger complex but instead exerts its effects through direct binding to target DNA sequences. This binding alters gene expression patterns impacting processes like inflammation and lipid metabolism.
Pathways
AEBP1 shows involvement in the NF-kB signaling pathway and the PI3K/AKT pathway. These pathways play critical roles in cell survival proliferation and immune response. AEBP1 modulates these signaling cascades through its direct interaction with NF-kB influencing downstream gene expression. Its activity shows overlap with proteins like AKT and IKK linking it to broader cellular processes and regulatory networks.
AEBP1 has associations with obesity and cardiovascular diseases. Its regulation of adipogenesis and lipid metabolism contributes to the development of obesity. This protein further impacts cardiovascular health through its modulation of inflammation an important factor in cardiovascular disease development. AEBP1 also shares connections with proteins like PPARγ and leptin which are pivotal in metabolic disorder progression.