Abcam, ab254980, Anti-DPF3 antibody

Size: 100µL
Rabbit Polyclonal DPF3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human DPF3 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DPF3 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q92784

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DPF3 also known as double PHD fingers 3 or BAF45C is a protein with a mass of approximately 44 kDa. It functions in chromatin remodeling and regulates transcription by altering DNA packaging. DPF3 expression varies but is found in tissues such as the heart and skeletal muscle. The protein contains two PHD finger domains that interact with histones and enable binding to specific sites on the chromatin.
Biological function summary
DPF3 plays a significant role in muscle differentiation and development. It forms part of the BAF (SWI/SNF) chromatin remodeling complex which regulates gene expression by modifying the structure of chromatin allowing transcription machinery to access DNA more effectively. DPF3 acts in response to signaling pathways that induce muscle cell differentiation contributing to the transcriptional activation of muscle-specific genes.
Pathways
Chromatin remodeling processes and muscle development pathways heavily involve DPF3. The protein links to the myogenic regulatory pathways where it interacts with other components like MYOD1 which is essential for muscle cell lineage determination. Additionally DPF3 affects the Wnt signaling pathway which is important in various developmental processes and coordinates cellular responses required for muscle growth.
DPF3 has connections to congenital heart diseases and certain types of cardiomyopathy. Mutations and altered expression levels in DPF3 affect heart muscle function linking it to proteins such as NKX2-5 another transcription factor critical for heart development. DPF3's interaction with these proteins can lead to malformations in cardiac structure and function emphasizing its importance in genomic integrity and organogenesis.