Abcam, ab256447, Recombinant Norovirus GII.4VP1 Antigen

Size: 100µg
Recombinant Norovirus GII.4VP1 Antigen is a Full Length protein, expressed in HEK 293 cells, with >95%, suitable for SDS-PAGE.
Key facts
Purity:>95% SDS-PAGE,
Expression system:HEK 293 cells,
Tags:Tag free,
Applications:SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Animal free:No,
Carrier free:No,
Storage buffer:pH: 7 - 8Constituents: 0.32% Tris HCl, 0.06% Sodium chloride

Product details:
Can be freeze-thawed up to 5 times.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Norovirus Capsid protein VP1 also known as the Norwalk Capsid protein is a major structural component of noroviruses. The mass of this protein is approximately 58 kilodaltons. It is expressed within the viral particles forming the outer shell or capsid which plays an important role in protection and infectivity of the virus. VP1 is also the main target for capsid ELISA tests which are employed for virus detection.
Biological function summary
Norovirus Capsid protein VP1 assembles into icosahedral particles forming the structure that encases the viral RNA. It works as part of a complex with other molecular groups to facilitate the virus’s entry into host cells by binding to histo-blood group antigens found on epithelial cells of the digestive tract. This protein’s structure allows it to adapt and evade the host immune response which plays role in the virus's infectivity.
Pathways
Norovirus Capsid protein VP1 involves in pathways related to viral replication and immune evasion. Inside the host it participates in interactions that inhibit immune signaling pathways. These interactions often involve proteins like the Golgi-associated mechanics to promote efficient assembly and release of viral particles. VP1's interaction with cellular machinery ensures ongoing propagation of the virus.
The Norovirus Capsid protein VP1 directly connects to gastroenteritis a leading cause of acute viral gastroenteritis. It links to disease progression by aiding viral invasion and persistence in the gastrointestinal tract. The VP1's interactions with the immune system and histo-blood group antigens contribute to high transmissibility and variability of infection severity among different individuals.