Abcam, ab256530, Anti-Nup107 antibody [EPR22877-21] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Nup107 antibody. Carrier free. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22877-21,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab256530 is the carrier-free version of
ab236634
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Nup107 also known as nucleoporin 107 is an important protein component of the nuclear pore complex (NPC). With a molecular mass of approximately 107 kDa it is a significant element in the structure of the NPC. Nup107 is expressed in various tissues throughout the body. It plays an essential mechanical role in the assembly and maintenance of NPCs facilitating the transport of macromolecules between the nucleus and the cytoplasm.
Biological function summary
Nup107 forms part of the Nup107-160 subcomplex which contributes to the NPC's structural integrity and function. This complex acts as a scaffold providing support for the overall architecture and positioning within the nuclear envelope. The presence of Nup107 influences nuclear-cytoplasmic transport which is key in regulation of gene expression and cell cycle progression. Nup107 ensures proper assembly serving as an anchor for other nucleoporins within the NPC.
Pathways
The Nup107 subcomplex plays a critical role in key cellular processes such as the cell cycle and gene expression regulation. It participates in the mitotic entry and exit by regulating nucleocytoplasmic transport of cell cycle regulators and transcription factors. Nup107 interacts with proteins like Nup133 and Nup160 which assist in these processes. The precise functioning of Nup107 is necessary for maintaining cellular homeostasis and successful progression through cell division.
Nup107 has links to conditions such as primary ovarian insufficiency and nephrotic syndrome. Mutations or aberrant expression of Nup107 disrupt NPC assembly or function potentially leading to impaired cellular transport and altered cellular functions. In ovarian insufficiency altered Nup107 expression affects folliculogenesis by disrupting nuclear transport of specific factors. In nephrotic syndrome Nup107 dysfunction impacts the glomerular filtration barrier with associated proteins like nephrin and podocin demonstrating interrelated pathological effects.